INHIBITION OF L-THYROXINE MONODEIODINATION BY THYROXINE ANALOGS*
نویسندگان
چکیده
منابع مشابه
Synthesis of thyroid hormone metabolites by photolysis of thyroxine and thyroxine analogs in the near UV.
Photolysis of thyroxine and its analogs in the near UV permitted synthesis in good yield of picogram to gram quantities of thyroid hormone metabolites. Preparation of the same metabolites by classical chemical synthesis requires multistep procedures. Specifically labeled metabolites of high specific activity (e.g., those carrying the label in the nonphenolic ring) were obtained by photolysis of...
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Objective(s): Severe injuries are often associated with tissue hypothyroidism, elevated damaging mediators in circulation, and broken gut epithelial barrier. However, the relationships between the hypothyroid state and gut epithelial damage are largely unknown. Therefore, in this study, we investigated the effects of L-thyroxine (T4) on in vitro models of intact and ...
متن کاملThyroxine Degradation. Iii. Competitive Inhibition of Thyroxine Degradation; Relationship of Structure to Inhibition.
Few attempts have been made to relate the structure of substances deiodinated by the systems in vitro which degrade thyroxine to specific structural requirements necessary for the reaction. In general, it has been found that several thyronine derivatives may be degraded by the rabbit muscle or rat liver microsomal thyroxine-degrading systems, but that none is more efficiently degraded than thyr...
متن کاملInhibition of hepatic binding of thyroxine by cholecystographic agents.
Subsequent to studies indicating that cholecystographic agents and sulfobromophthalein (BSP) inhibit uptake of thyroxine (T(4)) by rat liver slices, the effect of such compounds on hepatic storage of T(4) in man has been examined. After intravenous administration of [(125)I]T(4) to five normal subjects, hepatic radioactivity, estimated by external gamma counting, rose to a peak in approximately...
متن کاملMonodeiodination of thyroxine in the maternal and fetal dog kidneys and placenta.
We studied the monodeiodinating activities of the dog placenta and the pregnant dog kidney and compared them with those of the non-pregnant dog kidney and fetal kidney. Each tissue was homogenized in 50 mM Tris/HC1 buffer, pH 7.5. The homogenate (1 mg protein) was incubated with 1 microgram of T4 at 37 degrees C in the air for 15 min or 60 min in the presence of 5 mM DTT. The T3 and reverse T3 ...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1961
ISSN: 0021-9738
DOI: 10.1172/jci104342